Laboratory of heat and mass transfer in multicomponent dispersed systems

 History of the laboratory

The laboratory was established in 1995 and headed by Hiullinh E.V. (doctor of medical sciences, professor, corresponding member of NAS and NAMS of Ukraine, laureate of Ukranian SSR State Prize in the field of sciences and technology). From 1998 the laboratory was headed by Sharkova N.O. (candidate of technical sciences, senior research officer), who worked at the Institute of Engineering Thermophysics of NAS of Ukraine since 1962. From 2016 the laboratory is headed by Avdieieva L. (Engineering Science Doctor, senior research officer).

Over that period a modern experimental base was created in the laboratory to study hydromechanical, heat and mass transfer processes during dispersion, extraction and homogenization of complex multicomponent systems from plant and animal raw materials, as well as studies of heat and moisture transfer processes in multicomponent systems to determine special characterictics of dehydration process of liquid materials.

Scientific findings of the laboratory are based on the use of discrete-pulse energy input concept when processing complex heterogeneous media. This allows to optimize conditions of technological processes, purposefully manage processes of structure formation in dispersed systems, as well as ensure intensification of hydromechanical and mass transfer processes by creating conditions for  rational use of energy input.

The main scientific direction of the laboratory is development and implementation of energy-efficient technologies and equipment to produce new generation of products and agents in dry and liquid forms for food, pharmaceutical, cosmetic industries, veterinary medicine and agriculture.

The laboratory consists of 10 employees including 2 doctors of technical sciences and 3 candidates of technical sciences.

Publications: more than 220 scientific publications, including 2 monographs and more than 30 patents for inventions of Ukraine.


Kapnist (Zhelyabov) 2a, Kyiv, 03057

tel. (044) 453 28 44

fax. (044) 456 60 91

e -mail:

The main activities of the laboratory

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Main scientific activities of the laboratory are theoretical and experimental studies of heat and mass transfer processes when processing complex heterogeneous systems for creation of highly effective energy saving technologies and equipment for food, pharmaceutical, cosmetic industries, veterinary and agriculture.

Fundamental and applied studies include:

  • studies of hydromechanical and heat and mass transfer processes under conditions of multifuctor impact on materials during dispersion, homogenization, emulsification, hydration, extraction and hydrolysis of complex multicomponent systems for their intensification and ensuring optimal conditions for carrying out these processes;
  • studies of heat and mass transfer processes for lipid nano-vesicles formation with a given set of properties and structural characteristics to develop technologies and equipment for industrial production of highly effective agents with biologically active substances in nanoform; studies of heat and mass transfer processes in liquid multicomponent systems under influence of effects of hydrodynamic cavitation to intensify the processes;
  • modeling of drying process of single drops on system “drop-vapor-gas medium” to determine basic patterns of heat and moisture transfer during dehydration of various liquid systems in the heated coolant flow, determine thermoplastic and adhesive properties of dried particles under conditions of visualization of the process and deformation changes of the drop;
  • studies of features of heat and mass transfer when drying complex multicomponent heterogeneous systems, definition of rational modes and conditions of spray drying.

Commercial offers for cooperation

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Production technology of dry hydrolyzed protein product for special therapeutic and prophylactic nutrition of people with high protein needs.

A new domestic technology and regulatory documentation for industrial production of dry hydrolyzed protein product obtained by enzymatic hydrolysis of food plant and animal proteins has been developed. The amino acid composition of the product is close to FAO/WHO requirement  amino acid scoring pattern and contains up to 70 % of physiologically active peptides and free amino acids with a molecular weight of up to 6 kDa that are easily digested.

Protein hydrolysates are necessary for people with protein-energy deficiency such as postoperative or weakened patients in critical or burnt conditions. It is known that protein malnutrition in patients results in body’s resistance decrease, greater sensitivity to infections, poor wound healing, edema, etc. Disruption of protein nutritional status of surgical patients leads to increase in the number of postoperative disorders by 6 times, mortality – by 11 times.

The results of studies have confirmed that application of protein hydrolysates in medical practice has shown their high clinical effectiveness and decrease in frequency of postoperative and purulent septic complications.

In Ukraine there is no domestic industrial production of specialized therapeutic nutrition with hydrolyzed protein for patients with increased protein requirement.

The technology and regulatoty documentation for industrial production of dry hydrolyzed protein product of special and therapeutic and prophylactic nutrition for people with high protein needs is proposed.

Modern production technology of dry adapted infant formulas for therapeutic nutrition with hydrolyzed protein for special dietary purpose

A modern production technology of adapted formula for nutrition of infants allergic to animal and vegetable proteins, atopic allergy and severe disorders of digestive system of various genesis is proposed.

Advantages of the developed technology are:

– by technical and economic indicators:

  • reducing of energy consumption as compared with existing equipment;
  • shortening of duration of technological cycle;
  • several times lowering the cost of products compared with foreign analogues;
  • expansion of the range of domestic strategic products for the gene pool of Ukraine.

– by technological and functional properties:

  • increase of efficiency of directed structural modification of high protein system;
  • change the functional properties of the material;
  • increase the degree of dispersion and homogeneity of the protein-fat-carbohydrate heterogeneous system and increase its index of solubility;
  • reduction of allergenicity up to 80 % and increase in product digestibility.

The infant formulas are optimally balanced by the amino acid, fat, carbohydrate, mineral and vitamin compositions, that are close to breast milk. The products are also enriched with taurine, L-carnitine, choline, inositol, that are essential components for infants, and have prebiotic properties. The products meet requirements of Codex Alimentarius.

 Innovative production technology of lipid nanostructures and functional materials

An innovative technology has been developed for obtaining functional materials with lipid nano-containers, namely, liposomes 10-9-10-7 m in size for targeted delivery of biologically active substances directly to the cell for use in the medical, pharmaceutical, food industries, veterinary medicine and agriculture.

Advantages of the developed technology:

  • complex mechanical, hydrodynamic and hydroacoustic effects on lipid material, which can significantly improve the technological efficiency of the processes;
  • directed control of the process of formation of vesicular phospholipid nanostructures using the method of discrete-pulsed energy input;
  • obtaining functional materials with desired properties in industrial volumes;
  • reduction of electricity unit cost per unit of production.

We propose technology, equipment and regulatory documentation for industrial production of functional food products with lipid nanostructures.

 Resource-saving technology of dry protein-mineral food concentrate

A technology of natural protein-mineral concentrate in dry form that made of poultry secondary collagen-containing  raw is proposed.

Combination of original saving biotechnological techniques and DPEI-processing of feedstock allowed to significantly intensify extraction of protein and mineral substances and transfer up to 80 % of protein and 50 % of calcium to an aqueous solution. As a result, half of the protein goes into easily assimilated hydrolyzed form, where as calcium turns into biologically active citrate form.

The dry protein-mineral concentrate contains 85 % of protein, 10 % of mineral substances, 50-60 % of which are calcium and other micro and macro elements that are necessary for bone tissue.

Considering the wide industrial breeding of poultry in closed complexes and appropriate control, it is possible to assert about stability of composition of raw materials. Reliability, great potential and cheapness of source of raw materials should be noted; they are mainly used only for animal feed these days. The yield of protein-mineral complex from poultry secondary raw materials makes 80 % of dry weight. Standard equipment can be used in technological line to obtain natural protein-mineral concentrate.

Implementation of innovative projects

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A domestic energy-efficient technology of dry adapted infant formulas with hydrolyzed protein

The technology have been successfuly tested in industrial conditions and implemented at the Khorolsky milk factory of children’s products. The manufactured infant formulas are of high quality and affordability. Therapeutic effect of infant formulas with hydrolyzed protein have been studied at the State Institution «Institution of Pediatrics, Obstetrics and Gynecology of  NAMS of Ukraine» and  Gastroenterology Center of Children’s Clinical Hospital № 9 in Kiev. The results of biomedical studies have shown mild adaptation of infants to the formulas and their high biological value. Formulas meet the requrements of Codex Alimentarius, have pleasant taste and pronounced therapeutic effect in gastrointestinal disorders and allergic manifestations (stable clinical remission of  93,3 % of children).

 Energy-efficient technology of ointments with liposomes for external use in medicine and veterinary medicine

As a result of the work a design documentation has been developed, non-standard equipment has been manufactured and  experimental site for manufacturing ointments with liposomes has been installed. Technological regimes to produce fatty bases with liposomes and documentation have been developed. The technology has been clinically tested to verify effectiveness of their use as external medicines in human and veterinary medicine.

The results of clinical testsing of ointments with liposomes and biologically active components, which was carried out at the Scientific and Medical Center “Biokorektsiia” in humans, confirmed high efficiency and deep penetration of biologically active substances into the skin, rapid improvement of inflamed and dry skin.

As a result of clinical testing of ointments with biologically active substances in liposomal form, which was carried out at the Ukrainian enterprise “Koneprom”, it was found that treatment period for inflamed joints is reduced by 2-3 times, while consumption of product was reduced by 4-5 times.

 Technology and equipment for production of functional food products with lipid nanostructures

An effectiveness of lipid vesicular nanostructures and containing them functional products has been confirmed by results of clinical studies that were conducted at the Children’s City Gastroenterological Center of Children’s Clinical Hospital № 9 (Kiev) and the Institute of Otolaryngology im. prof. A.S. Kolomiichenka NAMS of Ukraine.

The results of testing have shown that the products can be successfully used as a therapeutic factor in complex therapy in medical institutions, as well as functional nutrition for therapeutic and preventive purposes for adults and children from 3 years old.

The technology was implemented at the workshop that manufacture therapeutic and prophylactic products (Children’s Clinical Hospital № 9, Kyiv) and private enterprise “Sonechko” (Kyiv).

 Technology and equipment for production of agents with lipid nanostructures for treating seeds and vegetative plants

Testing of the agents with lipid nanostructures was carried out at the State Enterprise «Kyiv Forest Research Station». Conducted here were the studies of effectiveness of agents with lipid nanostructures when growing seedlings of Scots pine (main forest forming species of Ukraine). Processing of seedlings by fertilizers in vesicular form (complex of ammonium nitrate and NPK-fertilizer), which was compared with ethanol form of fertilizers, has increased both biometric and weight indicators of seedlings: height – by 3-29 %; root length – by 1-9 %; root collar diameter – by 0,5–9 %; mass of the aerial part – by 3-42 %; including needles – by 7-36 %; root mass – by 9-33 %; average seedling weight – by 8-35 %.

Commission of the enterprise, which evaluated the results of experimental studies, believes that the use of vesicular forms of agents, which can be recommended for use in forestry for growing planting materials, allows significantly to reduce concentration of the agents and improve quality indicators for annual plants.

This makes it possible to reduce production costs for growing products and improve environmental safety. The use of agents in vesicular form for treating seeds and vegetative plants obtained by the method of DPEI is an effective and promising direction for their further implementation in enterprises that are profiled in crop production.

The technology was implemented at the State Enterprise «Kyiv Forest Research Station» (seeds and seedlings of Scots pine) and PLС «Scientific Research Institute of Soybean» (wheat, soybeans).

Technology and equipment for production of agents with lipid nanostructures for veterinary medicine

The work was carried out in cooperation with specialists of the National university of life and environmental sciences of  Ukraine (Kyiv).

Agents with lipid nanostructures, which have been manufactured according to developed technology, contribute to the rapid rescovery of structural and functional state of organs and tissues at cellular and subcellular levels, accelerate normalization of metabolic disorders, contribute to resilience of animals, reduce disease duration and rehabilitation period, prevent development of complications and recurrence of animals.

The results of the work were tested and implemented at the enterprise «Terezyne» (Kyiv oblast, Bila Tserkva Raion, Terezyne) during treatment of newborn calves that had indigestion disorders, at the PCL «Steikahro» (Kyiv oblast, Pereiaslav-Khmelnytskyi Raion) during treatment and prevention of internal diseases of pigs and at the teaching and research farm «Velykosnіtynske іm. O.V. Muzychenka» of the National university of life and environmental sciences of Ukraine.

Ongoing and completed projects

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The National Programme “Children of Ukraine”

The technologies for the production of balanced foods and prophylactic treatment for infants as well as special mixtures with desired properties for the children’s health food were developed .

Experimental batches of products were obtained. Extensive clinical tests of hypoallergenic baby food were made and showed an easy adaptation of children to the product, a significant therapeutic effect on children with obvious clinical signs of atopic dermatitis. The work was conducted in conjunction with the specialists of the Institute of Pediatrics, Obstetrics and Gynecology, Academy of Medical Sciences of Ukraine.

“The use of the effect of discrete – pulsed energy input in the development and implementation of energy saving technology production of dry multicomponent mixtures”

We were the first in Ukraine to propose industrial methods, equipment and designed regulatory documentation for the production of hypoallergenic baby food on the basis of the results of complex thermal and biochemical research.

Energy-saving technology of dry multi-component mixtures for children’s nutritional care is implemented at JSC “Khorol milk-canning combine of children’s products”.

 A scientific project “Research and Development functional product of onkoprotektive action” as a part of the target complex NAS program “The latest medical and biological problems and human environment’

Rational technological processes of extraction of isoflavones from soy isolate and termocalcium coagulation of proteins were establshed on the basis of comprehensive researches of heat and mass transfer process while obtaining a new protein onkoprotektive product.

Technology of the new soy protein onkoprotektive product and the standard technical documentation for its production were developed. Onkoprotektive action of the product was found in the result of experimental studies of the protein product developed in the Institute of Experimental Pathology, Oncology and Radiobiology named after Kavetsky R.S. The action includes the ability to inhibit the growth of tumors of the breast of experimental animals.

“Investigation of the influence of the method of discrete-pulse energy input in heterogeneous systems on the intensification of heat and mass transfer in industrial technologies”

Combining biotechnological techniques and discrete-pulse energy input treatment of secondary bone collagen raw material allowed to increase the surface of mass transfer, extract up to 100% of calcium andcollagen from bones.

The industrial technology of the food-protein-mineral concentrate, which contains 85 % of protein , 10 % of minerals , 60 % of which consist of calcium in easily digestible form is developed. The standard technical documentation for its production were developed. Clinical testing was conducted.

“Investigation of heat and mass transfer in discrete-pulse energy input in heterogeneous systems in order to develope nanotechnologies”

The investigations of the hydrodynamic and heat and mass transfer processes in discrete-pulse energy input into heterogeneous systems showed that it is possible to control the mechanism of self-organization of lipid nanostructures in a dissipative state of heterogeneous systems. Industrial technologes and equipment for productio of vesicular nanostructures. Were developed.

The efficiencient action of the vesicular forms of cytostatics and iron oxide nanopowders obtained by discrete-pulse energy input on the culture of cancer cells was tested at the Institute of Experimental Pathology , Oncology and Radiobiology named after Kavetsky R.S. The results showed an increase in cytotoxic activity of prototypes in vesicular form.

 The state target scientific and technical program “Nanotechnology and nanomaterials: “Investigations of heat and mass transfer processes in the creation of vesicular phospholipid nanostructures using the effect of discrete pulse of energy input of the meat and their implementation in the nanotechnology industry

Investigation of the influence of het mass transfer parameters of complex heterogeneous systems using effect of discrete pulse of energy input on the mechanism of formation of vesicular phospholipid nanostructures and determination of their physico- chemical properties was held.

The use of discrete pulse of energy input in developing energy- saving technologies in industrial production of lipid nanostructures and functional materials was proposed and implemented on the basis of the analytical and experimental results of research

The main regularities of the process of formation of vesicular nanostructures under the action of discrete pulse of energy input mechanisms were established; mathematical relations for predicting the properties and behavior of vesicular phospholipid nanostructures under the influence of thermal treatment regimes were obtained. The kinetic characteristics of the heat transfer process while drying of complex disperse systems with lipid nanostructures were determined; the use of the spray drying method in order to obtain the dry form of functional materials with lipid nanostructures was justified.

The use of lipid nanostructures, the obtained by pulse of energy input was proposed and approved in agriculture for targeted delivery of active substances into the cell seeds and growing plants, thereby reducing the concentration of the drugs, while improving plant productivity.

Main publications of department

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30 patents, 2 monographs, more than 220 articles.


  1. Долинский А.А. Исследования тепломасообменных процессов при создании везикулярных фосфолипидних наноструктур с использованием эффекта дискретно импульсного введения энергии и их реализация в промышленных нанотехнологиях / А.А. Долинский, Л.Ю. Авдеева, А.Ю. Чунихин, Н.И. Цвилиховский, А.В. Шлончак // Наноразмерные системы и наноматериалы: исследования в Украине.- К.: Академпериодика, 2014.-615-620 с.
  2. Микро- и наноуровневые процессы в технологиях ДИВЭ: Тематический сборник статей / под общей ред. А.А.Долинского; Институт технической теплофизики НАН Украины.-К.: Академпериодика, 2015.-464 с., 24 ил.

A list of main articles:

  1. Долинский А.А., Шаркова Н.О., Терлецкая Я.Т., Авдеева Л.Ю., Жукотский Э.К., Грищенко А.В. Способ промышленного получения липосомных наносистем с использованием эффекта дискретно-импульсного ввода энергии // Материалы Международной научно-практической конференции “Нанотехнология – технология XXI века”, М.:, Из-во МГОУ, 2006.- С. 100-103.
  2. Долинский А.А., Шаркова Н.А. Дискретно-импульсный метод получения наноструктур//Deformation & Fracture of Materials, M.: 2006.- №1. – P.247-248.
  3. Долинский А.А., Шаркова Н.А., Авдеева Л.Ю. Анализ и прогнозирования адаптивности липосомной системы при дискретно-импульсном вводе энергии // Сборник трудов V Международного междисциплинарного симпозиума «Прикладная синергетика в нанотехнологиях», Москва, 2008.-С.488-492.
  4. О.А.Орловский, С.П. Залеток, Н.О Шаркова. Ізофлавони сої можуть скасувати гальмування росту експериментальних пухлин, викликане ізолятом соєвого білка // К основам физического взаимодействия. Научные труды действ. членов Междунар. академии биоэнерготехнологий.-Вып.2.-Т.2.-Днепропетровск, 2010.
  5. Долінський А.А., Шаркова Н.О., Авдєєва Л.Ю., Чуніхін О.Ю. Дослідження властивостей фосфоліпідних наноструктур, отриманих з використанням ефекту дискретно-імпульсного введення енергії / Доповіді НАН України.-2011.-№2.-С. 71-75.
  6. Авдєєва Л.Ю. Методи підвищення ефективності технології отримання фосфоліпідних наноструктур, Наукові праці ОНАХТ, 2011, випуск 40, Т.2.-С.364-367.
  7. Авдеева Л.Ю. Иваницкий Г.К. Применение гидродинамической кавитации в технологическом процессе получения фосфолипидных наноструктур // Современная наука: исследования, идеи, результаты, технологии, 2011, №2 (7).-С.59-65.
  8. Шаркова Н.А., Авдеева Л.Ю. Дискретно-импульсный метод получения липидных наноструктур / Тезисы III Международной конференции «Наноструктурные материалы -2012: Россия-Украина-Беларусь», Санкт-Петербург, 19-22 ноября 2012 г., С.502
  9. Шаркова Н.А. Авдеева Л.Ю., Жукотский Э.К., Декуша А.В. Гипоаллергенные смеси «Малютка ГА» для детей грудного и раннего возраста /Материалы Междунар. междисциплинарной научной конференции «Биологически активные вещества и материалы: фундаментальные и прикладные вопросы получения и применения», Новый Свет, Крым, Украина, 2013.-Т. 2.-С.291.
  10. Долинський А.А. Авдеева Л.Ю., Шаркова Н.А. Использование механизмов дискретно-импульсного ввода энергии для создания промышленной технологии получения везикулярных наноструктур /Материалы Международной конференции «Украина-Россия-Сколково – Единое инновационное пространство», Киев, 2013.-С.104-105.
  11. Авдеева Л.Ю. Моделирование процесса формирования фосфолипидных везикулярных наноструктур/ Л.Ю.Авдеева, А.Ю.Чунихин // Известия КГТУ, 2013.-№29 .-С. 81-88.
  12. Козак М.М. Функціональний продукт з вторинної сировини переробки птиці/ М.М.Козак, Л.Ю.Авдєєва, Шаркова Н.О., Е.К.Жукотський // Наукові праці ОНАХТ, 2013 вип. 44, Т. 2.-С. 206-209.
  13. Шаркова Н.О. Білкові гідролізати для харчування дітей раннього віку/Н.О.Шаркова, Е.К.Жукотський, Л.Ю.Авдєєва, Г.В.Декуша // Наукові праці ОНАХТ, 2013 вип. 44, Т. 2.-С. 250-252.
  14. Авдєєва Л.Ю. Дослідження реологічних властивостей колоїдних дисперсних систем з фосфоліпідами/ Л.Ю.Авдєєва // Наукові праці ОНАХТ, 2013 вип. 43, Т. 2.-С. 17-20.
  15. Шаркова Н.О. Дослідження кінетики сушіння крапель водних розчинів білкових композицій/Н.О.Шаркова, Л.Ю.Авдєєва, Е,К. Жукотський, Т.Я.Турчина, Г.В. Декуша, Л.А.Костянец, О.В. Ткаченко // Наукові праці ОНАХТ, 2013 вип. 43, Т. 2.-С. 50-52.
  16. Авдєєва Л.Ю. Дослідження масообмінних процесів при кавітаційній обробці рідких гетерогенних середовищ / Л.Ю.Авдєєва// Промышленная теплотехника, 2013.-Т.35, №7.-С.190-194.
  17. Шаркова Н.А. Исследования и разработка технологии получения сухих липосомальных препаратов методом распылительной сушки / Н.А.Шаркова, Л.Ю.Авдеева, Э.К. Жукотский, Т.Я. Турчина // Промышленная теплотехника, 2013.-Т.35, №7.-С.213-218.
  18. Шаркова Н.А. Особенности производства гидролизованных белковых продуктов / Н.А.Шаркова, Э.К. Жукотский, А.В. Декуша, С.А.Иванов // Промышленная теплотехника, 2013.-Т.35, №7.-С.187-190.
  19. Долінський А.А. Використання кавітаційних технологій при обробці рідких гетерогенних систем /Долінський А.А., Авдєєва Л.Ю., Жукотський Э.К., Макаренко А.А.// Наукові праці ОНАХТ, 2014.- вип. 45, Т. 3.-С. 9-13.
  20. Долінський А.А. Сучасні методи впливу на структуруючі властивості складних матеріалів як об?єктів розпилювального сушіння /Долінський А.А., Турчина Т.Я., Жукотський Э.К. // Наукові праці ОНАХТ, 2014.- вип. 45, Т. 3.-С. 13-17.
  21. Декуша А.В. Теплофизические характеристики водных растворов гидролизованных белков/Декуша А.В., Жукотський Э.К., Иванов С.А.// Наукові праці ОНАХТ, 2014.- вип. 46, Т. 2.-С. 145-147.
  22. Долинский А.А. Гидродинамическая кавитация как метод интенсификации массообменных процессов /Долінський А.А., Авдєєва Л.Ю., Жукотський Э.К., Макаренко А.А. // Труды Международной научно-технической конференции «Проблемы ресурсо- и энергосберегающих технологий в промышленности и АПК», Иваново, 2014, Т.2.- С.469-472.
  23. Долінський А.А. Вплив гідродинамічної кавітації на обробку складних гетерогенних систем /Долінський А.А., Авдєєва Л.Ю., Жукотський Э.К., Макаренко А.А. // Промышленная теплотехника, 2014.-Т.36, №5.-С.5-9.
  24. Турчина Т.Я. Дослідження впливу процесів структуроутворення на ефективність зневоднення складних колоїдних систем методом розпилювання /Т.Я.Турчина Т.Я., Е.К. Жукотський //Промышленная теплотехника, 2014.-Т.36, №5.-С.27-33.
  25. Долинский А.А. Определение реологических свойств дисперсной системы с лецитином/Долинский А.А., Авдеева Л.Ю., Жукотский Э.К., Макаренко А.А.// Материалы Международной теплофизической школы», Таджикистан, Душанбе-Москва-Тамбов, 6-11 октября 2014.- С.325-332.
  26. Долинский А.А. Структурообразование частиц при получении сухой формы функционального питания /Долинский А.А., Авдеева Л.Ю., Шаркова Н.А.// Материалы IV Международной научной конференции «Наноструктурные материалы-2014: Беларусь-Россия-Украина», Минск, 7-10 октября 2014.- С.389.
  27. Авдеева Л.Ю. Роль фосфолипидов в функциональном питании / Л.Ю.Авдеева , И.Ф.Дейнека //Сборник научных трудов Sworld.- вып. 3(36), Т.8.-Иваново: Маркова АД.-2014.-С. 93-97.
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