Laboratory of heat and mass transfer in multicomponent dispersed systems
History of the laboratory
The laboratory was established in 1995 and headed by Hiullinh E.V. (doctor of medical sciences, professor, corresponding member of NAS and NAMS of Ukraine, laureate of Ukranian SSR State Prize in the field of sciences and technology). From 1998 the laboratory was headed by Sharkova N.O. (candidate of technical sciences, senior research officer), who worked at the Institute of Engineering Thermophysics of NAS of Ukraine since 1962. From 2016 the laboratory is headed by Avdieieva L. (Engineering Science Doctor, senior research officer).
Over that period a modern experimental base was created in the laboratory to study hydromechanical, heat and mass transfer processes during dispersion, extraction and homogenization of complex multicomponent systems from plant and animal raw materials, as well as studies of heat and moisture transfer processes in multicomponent systems to determine special characterictics of dehydration process of liquid materials.
Scientific findings of the laboratory are based on the use of discrete-pulse energy input concept when processing complex heterogeneous media. This allows to optimize conditions of technological processes, purposefully manage processes of structure formation in dispersed systems, as well as ensure intensification of hydromechanical and mass transfer processes by creating conditions for rational use of energy input.
The main scientific direction of the laboratory is development and implementation of energy-efficient technologies and equipment to produce new generation of products and agents in dry and liquid forms for food, pharmaceutical, cosmetic industries, veterinary medicine and agriculture.
The laboratory consists of 10 employees including 2 doctors of technical sciences and 3 candidates of technical sciences.
Publications: more than 220 scientific publications, including 2 monographs and more than 30 patents for inventions of Ukraine.
Contacts
Kapnist (Zhelyabov) 2a, Kyiv, 03057
tel. (044) 453 28 44
fax. (044) 456 60 91
e -mail: tbds_ittf@ukr.net
The main activities of the laboratory
Main scientific activities of the laboratory are theoretical and experimental studies of heat and mass transfer processes when processing complex heterogeneous systems for creation of highly effective energy saving technologies and equipment for food, pharmaceutical, cosmetic industries, veterinary and agriculture. Fundamental and applied studies include:
Commercial offers for cooperation
Production technology of dry hydrolyzed protein product for special therapeutic and prophylactic nutrition of people with high protein needs. A new domestic technology and regulatory documentation for industrial production of dry hydrolyzed protein product obtained by enzymatic hydrolysis of food plant and animal proteins has been developed. The amino acid composition of the product is close to FAO/WHO requirement amino acid scoring pattern and contains up to 70 % of physiologically active peptides and free amino acids with a molecular weight of up to 6 kDa that are easily digested. Protein hydrolysates are necessary for people with protein-energy deficiency such as postoperative or weakened patients in critical or burnt conditions. It is known that protein malnutrition in patients results in body’s resistance decrease, greater sensitivity to infections, poor wound healing, edema, etc. Disruption of protein nutritional status of surgical patients leads to increase in the number of postoperative disorders by 6 times, mortality – by 11 times. The results of studies have confirmed that application of protein hydrolysates in medical practice has shown their high clinical effectiveness and decrease in frequency of postoperative and purulent septic complications. In Ukraine there is no domestic industrial production of specialized therapeutic nutrition with hydrolyzed protein for patients with increased protein requirement. The technology and regulatoty documentation for industrial production of dry hydrolyzed protein product of special and therapeutic and prophylactic nutrition for people with high protein needs is proposed. Modern production technology of dry adapted infant formulas for therapeutic nutrition with hydrolyzed protein for special dietary purpose A modern production technology of adapted formula for nutrition of infants allergic to animal and vegetable proteins, atopic allergy and severe disorders of digestive system of various genesis is proposed. Advantages of the developed technology are: – by technical and economic indicators: – by technological and functional properties: The infant formulas are optimally balanced by the amino acid, fat, carbohydrate, mineral and vitamin compositions, that are close to breast milk. The products are also enriched with taurine, L-carnitine, choline, inositol, that are essential components for infants, and have prebiotic properties. The products meet requirements of Codex Alimentarius. Innovative production technology of lipid nanostructures and functional materials An innovative technology has been developed for obtaining functional materials with lipid nano-containers, namely, liposomes 10-9-10-7 m in size for targeted delivery of biologically active substances directly to the cell for use in the medical, pharmaceutical, food industries, veterinary medicine and agriculture. Advantages of the developed technology: We propose technology, equipment and regulatory documentation for industrial production of functional food products with lipid nanostructures. Resource-saving technology of dry protein-mineral food concentrate A technology of natural protein-mineral concentrate in dry form that made of poultry secondary collagen-containing raw is proposed. Combination of original saving biotechnological techniques and DPEI-processing of feedstock allowed to significantly intensify extraction of protein and mineral substances and transfer up to 80 % of protein and 50 % of calcium to an aqueous solution. As a result, half of the protein goes into easily assimilated hydrolyzed form, where as calcium turns into biologically active citrate form. The dry protein-mineral concentrate contains 85 % of protein, 10 % of mineral substances, 50-60 % of which are calcium and other micro and macro elements that are necessary for bone tissue. Considering the wide industrial breeding of poultry in closed complexes and appropriate control, it is possible to assert about stability of composition of raw materials. Reliability, great potential and cheapness of source of raw materials should be noted; they are mainly used only for animal feed these days. The yield of protein-mineral complex from poultry secondary raw materials makes 80 % of dry weight. Standard equipment can be used in technological line to obtain natural protein-mineral concentrate.
Implementation of innovative projects
A domestic energy-efficient technology of dry adapted infant formulas with hydrolyzed protein The technology have been successfuly tested in industrial conditions and implemented at the Khorolsky milk factory of children’s products. The manufactured infant formulas are of high quality and affordability. Therapeutic effect of infant formulas with hydrolyzed protein have been studied at the State Institution «Institution of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine» and Gastroenterology Center of Children’s Clinical Hospital № 9 in Kiev. The results of biomedical studies have shown mild adaptation of infants to the formulas and their high biological value. Formulas meet the requrements of Codex Alimentarius, have pleasant taste and pronounced therapeutic effect in gastrointestinal disorders and allergic manifestations (stable clinical remission of 93,3 % of children). Energy-efficient technology of ointments with liposomes for external use in medicine and veterinary medicine As a result of the work a design documentation has been developed, non-standard equipment has been manufactured and experimental site for manufacturing ointments with liposomes has been installed. Technological regimes to produce fatty bases with liposomes and documentation have been developed. The technology has been clinically tested to verify effectiveness of their use as external medicines in human and veterinary medicine. The results of clinical testsing of ointments with liposomes and biologically active components, which was carried out at the Scientific and Medical Center “Biokorektsiia” in humans, confirmed high efficiency and deep penetration of biologically active substances into the skin, rapid improvement of inflamed and dry skin. As a result of clinical testing of ointments with biologically active substances in liposomal form, which was carried out at the Ukrainian enterprise “Koneprom”, it was found that treatment period for inflamed joints is reduced by 2-3 times, while consumption of product was reduced by 4-5 times. Technology and equipment for production of functional food products with lipid nanostructures An effectiveness of lipid vesicular nanostructures and containing them functional products has been confirmed by results of clinical studies that were conducted at the Children’s City Gastroenterological Center of Children’s Clinical Hospital № 9 (Kiev) and the Institute of Otolaryngology im. prof. A.S. Kolomiichenka NAMS of Ukraine. The results of testing have shown that the products can be successfully used as a therapeutic factor in complex therapy in medical institutions, as well as functional nutrition for therapeutic and preventive purposes for adults and children from 3 years old. The technology was implemented at the workshop that manufacture therapeutic and prophylactic products (Children’s Clinical Hospital № 9, Kyiv) and private enterprise “Sonechko” (Kyiv). Technology and equipment for production of agents with lipid nanostructures for treating seeds and vegetative plants Testing of the agents with lipid nanostructures was carried out at the State Enterprise «Kyiv Forest Research Station». Conducted here were the studies of effectiveness of agents with lipid nanostructures when growing seedlings of Scots pine (main forest forming species of Ukraine). Processing of seedlings by fertilizers in vesicular form (complex of ammonium nitrate and NPK-fertilizer), which was compared with ethanol form of fertilizers, has increased both biometric and weight indicators of seedlings: height – by 3-29 %; root length – by 1-9 %; root collar diameter – by 0,5–9 %; mass of the aerial part – by 3-42 %; including needles – by 7-36 %; root mass – by 9-33 %; average seedling weight – by 8-35 %. Commission of the enterprise, which evaluated the results of experimental studies, believes that the use of vesicular forms of agents, which can be recommended for use in forestry for growing planting materials, allows significantly to reduce concentration of the agents and improve quality indicators for annual plants. This makes it possible to reduce production costs for growing products and improve environmental safety. The use of agents in vesicular form for treating seeds and vegetative plants obtained by the method of DPEI is an effective and promising direction for their further implementation in enterprises that are profiled in crop production. The technology was implemented at the State Enterprise «Kyiv Forest Research Station» (seeds and seedlings of Scots pine) and PLС «Scientific Research Institute of Soybean» (wheat, soybeans). Technology and equipment for production of agents with lipid nanostructures for veterinary medicine The work was carried out in cooperation with specialists of the National university of life and environmental sciences of Ukraine (Kyiv). Agents with lipid nanostructures, which have been manufactured according to developed technology, contribute to the rapid rescovery of structural and functional state of organs and tissues at cellular and subcellular levels, accelerate normalization of metabolic disorders, contribute to resilience of animals, reduce disease duration and rehabilitation period, prevent development of complications and recurrence of animals. The results of the work were tested and implemented at the enterprise «Terezyne» (Kyiv oblast, Bila Tserkva Raion, Terezyne) during treatment of newborn calves that had indigestion disorders, at the PCL «Steikahro» (Kyiv oblast, Pereiaslav-Khmelnytskyi Raion) during treatment and prevention of internal diseases of pigs and at the teaching and research farm «Velykosnіtynske іm. O.V. Muzychenka» of the National university of life and environmental sciences of Ukraine.
Ongoing and completed projects
The National Programme “Children of Ukraine” The technologies for the production of balanced foods and prophylactic treatment for infants as well as special mixtures with desired properties for the children’s health food were developed . Experimental batches of products were obtained. Extensive clinical tests of hypoallergenic baby food were made and showed an easy adaptation of children to the product, a significant therapeutic effect on children with obvious clinical signs of atopic dermatitis. The work was conducted in conjunction with the specialists of the Institute of Pediatrics, Obstetrics and Gynecology, Academy of Medical Sciences of Ukraine. “The use of the effect of discrete – pulsed energy input in the development and implementation of energy saving technology production of dry multicomponent mixtures” We were the first in Ukraine to propose industrial methods, equipment and designed regulatory documentation for the production of hypoallergenic baby food on the basis of the results of complex thermal and biochemical research. Energy-saving technology of dry multi-component mixtures for children’s nutritional care is implemented at JSC “Khorol milk-canning combine of children’s products”. A scientific project “Research and Development functional product of onkoprotektive action” as a part of the target complex NAS program “The latest medical and biological problems and human environment’ Rational technological processes of extraction of isoflavones from soy isolate and termocalcium coagulation of proteins were establshed on the basis of comprehensive researches of heat and mass transfer process while obtaining a new protein onkoprotektive product. Technology of the new soy protein onkoprotektive product and the standard technical documentation for its production were developed. Onkoprotektive action of the product was found in the result of experimental studies of the protein product developed in the Institute of Experimental Pathology, Oncology and Radiobiology named after Kavetsky R.S. The action includes the ability to inhibit the growth of tumors of the breast of experimental animals. “Investigation of the influence of the method of discrete-pulse energy input in heterogeneous systems on the intensification of heat and mass transfer in industrial technologies” Combining biotechnological techniques and discrete-pulse energy input treatment of secondary bone collagen raw material allowed to increase the surface of mass transfer, extract up to 100% of calcium andcollagen from bones. The industrial technology of the food-protein-mineral concentrate, which contains 85 % of protein , 10 % of minerals , 60 % of which consist of calcium in easily digestible form is developed. The standard technical documentation for its production were developed. Clinical testing was conducted. “Investigation of heat and mass transfer in discrete-pulse energy input in heterogeneous systems in order to develope nanotechnologies” The investigations of the hydrodynamic and heat and mass transfer processes in discrete-pulse energy input into heterogeneous systems showed that it is possible to control the mechanism of self-organization of lipid nanostructures in a dissipative state of heterogeneous systems. Industrial technologes and equipment for productio of vesicular nanostructures. Were developed. The efficiencient action of the vesicular forms of cytostatics and iron oxide nanopowders obtained by discrete-pulse energy input on the culture of cancer cells was tested at the Institute of Experimental Pathology , Oncology and Radiobiology named after Kavetsky R.S. The results showed an increase in cytotoxic activity of prototypes in vesicular form. The state target scientific and technical program “Nanotechnology and nanomaterials: “Investigations of heat and mass transfer processes in the creation of vesicular phospholipid nanostructures using the effect of discrete pulse of energy input of the meat and their implementation in the nanotechnology industry“ Investigation of the influence of het mass transfer parameters of complex heterogeneous systems using effect of discrete pulse of energy input on the mechanism of formation of vesicular phospholipid nanostructures and determination of their physico- chemical properties was held. The use of discrete pulse of energy input in developing energy- saving technologies in industrial production of lipid nanostructures and functional materials was proposed and implemented on the basis of the analytical and experimental results of research The main regularities of the process of formation of vesicular nanostructures under the action of discrete pulse of energy input mechanisms were established; mathematical relations for predicting the properties and behavior of vesicular phospholipid nanostructures under the influence of thermal treatment regimes were obtained. The kinetic characteristics of the heat transfer process while drying of complex disperse systems with lipid nanostructures were determined; the use of the spray drying method in order to obtain the dry form of functional materials with lipid nanostructures was justified. The use of lipid nanostructures, the obtained by pulse of energy input was proposed and approved in agriculture for targeted delivery of active substances into the cell seeds and growing plants, thereby reducing the concentration of the drugs, while improving plant productivity.
Main publications of department
30 patents, 2 monographs, more than 220 articles. Monographs: A list of main articles:
